Formulation and Evaluation of Oral Dispersible Tablets of Zidovudine with different Superdisintegrants

Oral dispersible tablets (ODTs) are patient friendly dosage form that rapidly disintegrate or dispersed in mouth without the need of water. In the present investigation eight ODT formulations of zidovudine, an antiretroviral drug, were prepared using different superdisintegrants viz. Crospovidone (PPXL), Crosscarmellose sodium (Ac-di-sol) and sodium starch glycollate by direct compression method. The effects of disintegrants in different concentration on the release profile of zidovudine ODTs were studied. Developed ODTs were studied for their physicochemical properties and in vitro drug release profile. The studied parameters were found to be satisfactory for all ODT formulations of zidovudine. Disintegration time for all the formulations was found to be less than 60 seconds. Disintegration time for all ODTs decreased with increase in disintegrant concentration. ODTs prepared using Ac-di-sol 6% possessed least disintegration time (13.9), offered better dissolution profile than that of all the ODTs formulations developed in the present investigation and that of marketed conventional tablet formulation of zidovudine. Ac-di-sol when tried in concentration above 6% resulted in an increase in disintegration time instead of further decreasing it. Accelerated studies proved that the optimized formulation was stable even after 3 months.